About CRISPR Therapeutics The mission of CRISPR Therapeutics is to develop transformative gene-based medicines for patients with serious diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, … Vertex will also provide a $30 million investment in CRISPR, which is a private company. The US giant Vertex Pharmaceuticals is expanding an existing collaboration with the Swiss company CRISPR Therapeutics, paying up to €890M ($1B) to develop treatments for genetic diseases causing muscle weakness using the gene editing tool CRISPR/Cas9. In June last year, Vertex expanded an existing four-year collaboration with CRISPR to develop new treatments for genetic causes of human diseases. It could be a long time before we know if Vertex and CRISPR have a new marketable treatment option for sickle cell disease. CRISPR is also eligible to receive future development, regulatory and sales milestones and royalty payments on future sales. This technology may offer the ability to directly modify or correct the underlying disease-associated changes in the human genome for the potential treatment of a large number of both rare and common diseases. Vertex already has a CRISPR–Cas gene therapy in the clinic, CTX001, through a 2015 deal with CRISPR Therapeutics. In the years leading up to the trial, Patient 1 required 34 units of red blood cells annually and Patient 2 needed transfusions at a rate of 61 units per year. Vertex and CRISPR Therapeutics began a research collaboration in October of 2015 focused on the use of CRISPR’s gene editing technology, known as CRISPR-Cas9, to discover and develop potential new treatments aimed at the underlying genetic causes of human disease. While Vertex believes the forward-looking statements contained in this press release are accurate, these forward-looking statements represent the company's beliefs only as of the date of this press release and there are a number of factors that could cause actual events or results to differ materially from those indicated by such forward-looking statements. In the Climb-111 trial treating transfusion-dependent beta-thalassemia (TDT), CTX001 drastically reduced patients' dependence on frequent blood transfusions. It is working on a CRISPR-based, possibly curative treatment for sickle cell disease and beta-thalassemia in partnership with CRISPR Therapeutics. CRISPR Therapeutics and Vertex Present New Data for Investigational CRISPR/Cas9 Gene-Editing Therapy, CTX001™ at American Society of Hematology Annual Meeting and Exposition, Together With Publication in the New England … Specifically for hemoglobinopathies, including treatments for sickle cell disease, Vertex and CRISPR will equally share all research and development costs and sales, with CRISPR Therapeutics leading commercialization efforts in the U.S. For all other diseases, Vertex will lead all development and global commercialization activities. Returns as of 02/05/2021. About the Collaboration Under the terms of the collaboration, Vertex and CRISPR will jointly use the CRISPR-Cas9 technology to discover and develop potential new treatments that correct defects in specific gene targets known to cause or contribute to particular diseases. Cory is a long-term minded analyst focused on the Healthcare Sector. The investment will provide Vertex with an ownership stake in CRISPR. Emmanuelle Charpentier, Ph.D., one of CRISPR Therapeutics’ scientific founders, co-invented the CRISPR-Cas9 technology and is the recipient of multiple prestigious awards in recognition of the potential contribution that the CRISPR-Cas9 technology may have on global health. Vertex disclaims any obligation to update the information contained in this press release as new information becomes available. Dive Brief: Vertex Pharmaceuticals Inc. has selected CTX001 as the first drug it will co-develop and commercialize with CRISPR Therapeutics AG per the companies' ongoing collaboration. CRISPR Therapeutics and Vertex entered into a strategic research collaboration in 2015 focused on the use of CRISPR/Cas9 to discover and develop potential new treatments aimed at the underlying genetic causes of human disease. The collaboration will evaluate the use of CRISPR-Cas9 across multiple diseases where targets have been validated through human genetics. CTX001 represents the first treatment to emerge from the joint research program. Treatment with CTX001 should lead to the body producing healthy fetal hemoglobin to replace the faulty hemoglobin at the source of their blood disorders. This morning, Vertex said it expanded its collaboration with CRISPR to discover and develop gene editing therapies for the treatment of DMD and DM1. The initial focus of the collaboration will be on the use of CRISPR-Cas9 to potentially correct the mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene known to result in the defective protein that causes CF and to edit other genes that contribute to the disease. Founded in 1993 by brothers Tom and David Gardner, The Motley Fool helps millions of people attain financial freedom through our website, podcasts, books, newspaper column, radio show, and premium investing services. Vertex and CRISPR will focus their initial gene editing research on discovering treatments to address the mutations and genes known to cause and contribute to cystic fibrosis and sickle cell disease. Additionally, the companies will seek to discover and develop gene-based treatments for hemoglobinopathies, including sickle cell disease. Founded in 1989 in Cambridge, Mass., Vertex today has research and development sites and commercial offices in the United States, Europe, Canada and Australia. Vertex will initially invest $75 million in cash and take a $30 million equity stake in venture-backed CRISPR Therapeutics. In the Climb-121 trial treating severe sickle cell disease, an infusion of CTX001 appeared successful for the first two patients treated. Vertex and CRISPR Therapeutics' treatment, CTX001, is made from a patient’s own stem cells, which are harvested and then edited to increase fetal hemoglobin levels in … Gene therapy took another public step forward during a virtual presentation at a scientific conference on Friday. Vertex will fund 100 percent of the development expenses of licensed treatments. Vertex and CRISPR will also evaluate a specified number of other genetic targets as part of the collaboration. Buy These 5 Hot Biotech Stocks Now, Here's How the Genetic Testing Industry Can Get Even Bigger, 3 Biotech Stocks That Could Explode Higher in 2021. The collaboration will evaluate the use of CRISPR-Cas9 across multiple diseases where targets … This explosion in interest could … The candidate is an investigational ex vivo CRISPR gene-edited therapy, which is currently being developed for treating sickle cell disease ("SCD") and transfusion-dependent beta thalassemia ("TDT") in partnership with Vertex Pharmaceuticals. About the CRISPR-Vertex Collaboration CRISPR Therapeutics and Vertex entered into a strategic research collaboration in 2015 focused on the use of CRISPR/Cas9 to discover and develop potential new treatments aimed at the underlying genetic causes of human disease. For CTX001, CRISPR and Vertex will equally share all research and development costs and profits worldwide. It is also one of the first companies to begin testing CRISPR/Cas9 in humans through its partnership with local startup CRISPR Therapeutics (Nasdaq: CRSP). Crispr and Vertex believe Crispr gene editing will win out because of its precision and durability, although that will obviously need to be proven in the clinic. Cumulative Growth of a $10,000 Investment in Stock Advisor, CRISPR Therapeutics and Vertex Pharmaceuticals Deliever New CTX001 Data @themotleyfool #stocks $CRSP $VRTX, Better Buy: CRISPR Therapeutics vs. Editas Medicine, Got $5,000 and 5 Years to Wait? Vertex Partnership Academies seeks to be the first-of-its-kind charter management organization and partnership network of exceptional, tuition-free International Baccalaureate (IB) public charter high schools that offer pathways to college completion and/or career development, and empowers its graduates to lead lives of meaning and purpose. Now, VRTX stock … “As a company founded on innovative science, we’re excited to begin this collaboration with CRISPR, as it puts us at the forefront of what we believe may be a fundamental change in the future treatment of disease -- using gene editing technologies to address the underlying genetic causes of many diseases.”, “Vertex has a track record of developing innovative medicines for cystic fibrosis and other serious diseases, making them a great partner to accelerate the therapeutic promise of gene editing,” said Rodger Novak, M.D., Chief Executive Officer of CRISPR Therapeutics. Vertex revealed plans to acquire Exonics Therapeutics for roughly $1 billion, in addition, to invest an added up-to $1.175 billion to increase a 3 1/2-year-old, potentially $2.5 billion-plus partnership with CRISPR Therapeutics that has led to the first clinical trial of a gene-editing therapy candidate funded by U.S. business. Vertex will pay CRISPR $75 million in cash as part of its up-front commitment. Crispr Therapeutics and Vertex Pharmaceuticals unveiled promising results for a gene-editing approach to blood diseases Wednesday.The news sent CRSP stock flying higher. The deal gives Vertex an … www.crisprtx.com. Discovery activities will be conducted primarily by CRISPR, and the related expenses will be fully funded by Vertex. At 15 months following a single infusion of CTX001, patient 1 still hasn't required a transfusion. CTX001 represents the first treatment to emerge from the joint research program. Under the terms of this strategic collaboration and license agreement, Vertex will pay $175 million upfront for the exclusive worldwide rights to CRISPR Therapeutics’ existing and future intellectual property including foundational CRISPR/Cas9 technology, novel endonucleases, single and double cut guide RNAs, and AAV vectors for DMD and DM1 gene editing products. Cas9 is a CRISPR-associated endonuclease (an enzyme) known to act as the “molecular scissors” that cut and edit, or correct, disease-associated DNA in a cell. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc.CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, … It could be a long time before we know if Vertex and CRISPR have a new marketable treatment option for sickle cell disease. CRISPR Therapeutics Receives Grant to Advance In Vivo CRISPR/Cas9 Gene Editing Therapies for HIV. Our therapeutic approach aims to cure diseases at the molecular level using the breakthrough gene editing technology called CRISPR-Cas9. Special Note Regarding Forward-looking Statements This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, including, without limitation, Dr. Altshuler’s statements in the second paragraph of the press release, Dr. Novak’s statements in the third paragraph of the press release and the information provided regarding the future development of treatments for genetic diseases using the CRISPR-Cas9 technology. Moving forward, Vertex and CRISPR … For each of the up to six treatments in-licensed for development, Vertex will pay future development, regulatory and sales milestones of up to $420 million as well as royalty payments on future sales. CRISPR Therapeutics and Vertex entered into a strategic research collaboration in 2015 focused on the use of CRISPR/Cas9 to discover and develop potential new treatments aimed at the underlying genetic causes of human disease. Copyright, Trademark and Patent Information. X. For additional information and the latest updates from the company, please visit www.vrtx.com. CTX001 represents the first potential treatment to emerge from the joint research program. A guide RNA directs the Cas9 molecular scissors to the exact site of the disease-associated mutation. CRISPR Therapeutics and Vertex have presented updated data on the first patients treated with their CRISPR/Cas9 gene-editing therapy. CRISPR Therapeutics is not responsible for the content or availability of third-party sites. Stock Advisor launched in February of 2002. Vertex disclaims any obligation to update the information contained in this press release as new information becomes available. The collaboration also provides Vertex with an observer seat on the CRISPR Board of Directors, which will be filled by Dr. Altshuler. As part of the collaboration, Vertex made an up-front commitment of $105 million to CRISPR, including $75 million in cash and a $30 million equity investment. Vertex and CRISPR will collaborate on the research, development and commercialization of treatments for hemoglobinopathies that emerge from the collaboration. CRISPR Therapeutics' (CRSP) lead gene-editing candidate CTX001, being developed for treating SCD and TDT, holds potential. Vertex will also provide a $30 million investment in CRISPR, which is a private company. Vertex will pay CRISPR $75 million in cash as part of its up-front commitment. Those risks and uncertainties include, among other things, that data may not support further development of the gene-based treatments subject to the collaboration due to safety, efficacy or other reasons, and other risks listed under Risk Factors in Vertex's annual report and quarterly reports filed with the Securities and Exchange Commission and available through the company's website at www.vrtx.com. The Climb-121 trial will look for fetal hemoglobin levels of 20% or higher sustained for at least three months. The investment will provide Vertex with an ownership stake in CRISPR. About Gene Editing with CRISPR-Cas9 “CRISPR” refers to Clustered Regularly Interspaced Short Palindromic Repeats that occur in the genome of certain bacteria, from which the system was discovered. It has a strong partner in Vertex. Vertex will have exclusive rights to license up to six new CRISPR-Cas9-based treatments that emerge from the collaboration. They all either resolved or were resolving at the time of the statement, but Vertex decided it would not be feasible to safely reach exposure levels. Shares of CRISPR Therapeutics have rallied 87.3% in the past three months compared with the ... ("TDT") in partnership with Vertex Pharmaceuticals. We have licensed the foundational CRISPR-Cas9 patent estate for human therapeutic use from our scientific founder, Dr. Emmanuelle Charpentier. CRISPR Therapeutics (NASDAQ:CRSP) and Vertex Pharmaceuticals (NASDAQ:VRTX) presented updated results from studies with CTX001, the first CRISPR-based gene-editing therapy to reach human-stage testing. CRISPR Therapeutics and Vertex's findings could put pressure on Bluebird bio, which won European approval for its gene therapy Zynteglo in beta thalassemia, but has hit multiple delays in the U.S. Bluebird's gene therapies have shown promise for both diseases, although the company has had to fine tune its approach in sickle cell. Where Will CRISPR Therapeutics Be in 10 Years? Market data powered by FactSet and Web Financial Group. Investors: Michael Partridge, 617-341-6108 or Kelly Lewis, 617-961-7530 or Eric Rojas, 617-961-7205, Media: mediainfo@vrtx.com Zach Barber: 617-341-6992, CRISPR MEDIA CONTACTS: MacDougall Biomedical Communications Kari Watson in US – kwatson@macbiocom.com +1 (781) 235-3060 Anca Alexandru in Europe – aalexandru@macbiocom.com +49 (89) 2424-3494, Interested in joining our team? With our multi-disciplinary team of world-renowned academics, drug developers and clinicians, we are uniquely positioned to translate CRISPR-Cas9 technology into human therapeutics. BOSTON AND CAMBRIDGE, MASS – October 26, 2015 – Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) and CRISPR Therapeutics today announced that the two companies have entered into a strategic research collaboration focused on the use of CRISPR’s gene editing technology, known as CRISPR-Cas9, to discover and develop potential new treatments aimed at the underlying genetic causes of human disease. Careers at CRISPR, © 2021 CRISPR Therapeutics. The other scientific co-founders of CRISPR are Craig Mello, Ph.D., Chad Cowan, Ph.D., Matthew Porteus, M.D., Ph.D., and Daniel Anderson, Ph.D. About Vertex Vertex is a global biotechnology company that aims to discover, develop and commercialize innovative medicines so people with serious diseases can lead better lives. CTX001 represents the first gene-based treatment that Vertex exclusively licensed from CRISPR Therapeutics as part of the collaboration. The companies have resumed dosing at some locations and they expect to report more data in the second half of the year. For five years in a row, Science magazine has named Vertex one of its Top Employers in the life sciences. In addition to our clinical development programs focused on cystic fibrosis, Vertex has more than a dozen ongoing research programs aimed at other serious and life-threatening diseases. We are headquartered in Basel, Switzerland, our R&D operations are in Cambridge, Massachusetts and we have corporate offices in London, United Kingdom. He genuinely enjoys cutting through the complexity to help everyday investors make better decisions. Thanks to these new studies, beta thalassaemia and sickle cell join Duchenne muscular dystrophy, haemophilia and choroideremia as hotly contested targets for gene therapy developers. Use from our scientific founder, Dr. Emmanuelle Charpentier for a year and a half treating severe sickle cell.. 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